PMC

(A–C) Treatments included weekly single-point ablation (single, n = 8), circle pattern ablation (circle, n = 4), single-point ablation plus Dox-LCL (single + LCL, n = 4), circle ablation plus Dox-LCL (circle + LCL, n = 4), no ultrasound and no drug (no tx, n = 8), or Dox-LCL only (LCL, n = 4). Dox-LCL (or control saline) was injected biweekly (4 ablations and 8 injections total). (B) At 180 days after the start of treatment/152 days after completion (study end point), tumors could not be detected in mice treated with circle ablation plus Dox-LCL. In all other groups, tumor growth was delayed, but a complete response was not typically achieved. (C) At study end point, all (n = 4) mice treated with circle ablation plus Dox-LCL and 25% (1 of 4) of mice treated with single-point ablation plus Dox-LCL survived. (D–F) TSL therapy combined with ablation. (D) Treatments included weekly: single-point ablation plus Dox-TSL (single + TSL, n = 4), circle ablation plus Dox-TSL (circle + TSL, n = 4), circle ablation preceded by hyperthermia and Dox-TSL (hyp + circle + TSL, n = 4), no ultrasound and no drug (no tx, n = 4), or Dox-TSL only (n = 4) for a period of 4 weeks. (E and F) At study end point, tumors could not be detected in all mice treated with circle ablation plus Dox-TSL combined with hyperthermia. In all other groups, tumor growth was delayed, and a complete response was also achieved in 75% of mice treated with circle ablation plus Dox-TSL and 25% of mice treated with single-point ablation plus Dox-TSL. Data are pooled from 6 experiments.

Correlation of troponin T (TnT) and cardiac creatin kinase (CKMB) with total ablation time. Upper panels, relationship between serum troponin T level and total ablation time. Lower panels, relationship between serum CKMB level and total ablation time. Plots show significant correlations between the myocardial marker levels and total ablation time in all groups. Y-axis serum levels of troponin T (micrograms per liter) or CKMB (micrograms per liter). X-axis total ablation time (seconds). CIR, RMI, RMN; see Fig. 

Multiplanar image reconstruction along axis of microwave antenna to measure ablation zone size. A, Oblique axial CT image shows elliptical ground-glass opacity from pulmonary ablation and provides total length of ablation zone (double arrow). B, Oblique coronal CT image provides cranial-caudal dimension of ablation zone (double arrow). C, Image is magnified view of ablation zone from, B, and provides dimensions of ablation zone medial and lateral to antenna. Note how ground glass-opacity of pulmonary ablation zone extends to heart surface in, C (double arrows).

A, Total population. B, 4 groups according to randomization. C, order of ablation of right-sided or left-sided PV first. D, order of ablation of CF blindness